unnamedProfessor Alexandros Makriyannis

Professor and Behrakis Trustee Chair in Pharmaceutical Biotechnology, Director of the Center for Drug Discovery

 

 

 

 

Education

Ph.D. Medicinal Chem., Univ. of Kansas (1967)
Post-doctoral, Organic Chem., U. California, Berkeley (1967-69)

Honors & Awards
Research Scientist Award, NIDA (1990-95; 1995-2000)
Fellow, American Association for the Advancement of Science (1993)
President, International Cannabinoid Research Society (ICRS) (1993)
Distinguished Scientist Award, University of Connecticut Alumni (1996)
Fellow, American Association of Pharmaceutical Sciences (1997)
National Institute of Health MERIT Awards (1997-2007, 2007-2017)
Senior Scientist NIDA Award (2000-2011)
Research Achievement Award in Drug Design and Discovery, American Association of Pharmaceutical Scientists (AAPS) (2002)
Honorary Doctorate of Philosophy, University of Athens, Greece (2005)
Mechoulam Life Achievement Award in Cannabinoid Research (ICRS) (2006)
Kenneth E. Avis Award in Medicinal Chemistry (2007)
Marquis Who’s Who in Science and Engineering (2007)
ACS Award in Medicinal Chemistry (2012)
Annual NU Award for Excellence in Research and Creativity (2012)
ACS Medicinal Chemistry Hall of Fame (2013)
Highly Cited Researcher, Thomson Reuters (2014)
Distinguished Professor, Northeastern University (2015)
AAPS Distinguished Pharmaceutical Scientist Award (2015)

CV
Current CV and Selected Publications

All Publications:

http://www.ncbi.nlm.nih.gov/sites/myncbi/alexandros.makriyannis.1/bibliography/40721184/public/?sort=date&direction=ascending

FEDERAL GRANTS (Active)
R01 DA031020 (PI) FAAH: Medications Development for Cannabis-Related Disorders (9/30/10-8/31/16)
R37 DA023142 (PI) Cannabinergic Medications for Methamphetamine Addiction (5/1/07-4/30/17)
P01 DA09158 (PI) Endocannabinoid Active Sites as Therapeutic Targets (9/30/94-6/30/19)
R01 DA003801 (PI) Molecular Basis of Cannabinoid Activity (4/1/92-2/28/18)
R13 DA040423 (PI) Chemistry and Pharmacology of Drugs of Abuse Symposium (7/15/15-6/30/20)

FOUNDATION GRANTS
Klarman Foundation, Cannabinoid Medications for Anorexia Nervosa (6/1/14-2/28/17)
Alzheimer’s Drug Discovery Foundation, Fatty Acid Amide Hydrolase Inhibitors as AD Medications (9/1/15-8/31/16)

INDUSTRIAL GRANTS
Endo Pharmaceuticals CB2 Selective Agonists
Glaxo Wellcome Design and Synthesis of Antineoplastic Alkyl Lysophospholipids
Glaxo Wellcome Antineoplastic Ether Lipids Molecular Mechanisms of Action
WHO World Health Organization Research Award
Pfizer Central Research Development of Porcine Somatotropin Receptor Binding Assays

UNITED STATES ISSUED PATENTS (First Author):

  1. Heteropyrrole analogs acting on cannabinoid receptors. US 8853205 (October 7, 2014)
  2. Heteropyrrole analogs acting on cannabinoid receptors. US 8410097 (April 2, 2013)
  3. Therapeutic applications of fatty acid amide hydrolase inhibitors. US 8293724 (October 23, 2012)
  4. CB1 receptor antagonists and uses thereof. US 8293211 (October 23, 2012)
  5. Cannabinergic lipid ligands. US 8202893 (June 19, 2012)
  6. Antiprotozoal ring-substituted phospholipids. US 8097752 (January 17, 2012).
  7. Novel heteropyrrole analogs acting on cannabinoid receptors. US 8084451 (December 27, 2011)
  8. Pyrazole derivatives as cannabinoid receptor antagonists. US 8084467 (December 27, 2011)
  9. Inhibitors of the anandamide transporter. US 7897598 (2011)
  10. Receptor selective cannabimimetic aminoalkylindoles. US 7820144 (2010)
  11. Pyrazole analogs acting on cannabinoid receptors. US 7745440 (June 29, 2010)
  12. Peripheral cannabinoid receptor (CB2) selective ligands. US 7741365 (June 22, 2010)
  13. Heteroindanes: a new class of potent cannabimimetic ligands. US 7666867 (February 23, 2010).
  14. Inhibitors of the anandamide transporter. US 7589220 (September 15, 2009)
  15. Bicyclic cannabinoids. US 7446229 (November 4, 2008)
  16. Pyrazole analogs acting on cannabinoid receptors. US 7393842 (July 1, 2008)
  17. Bicyclic cannabinoid agonists for the cannabinoid receptor. US 7335688 (February 26, 2008)
  18. Cannabimimetic ligands. US 7329651 (February 12, 2008)
  19. Bicyclic and tricyclic cannabinoids. US 7285683 (October 23, 2007)
  20. Retro-anandamides, high affinity and stability cannabinoid receptor ligands. US 7276613 (October 2, 2007)
  21. Cannabimimetic indole derivatives. US 7241799 (July 10, 2007)
  22. Keto cannabinoids with therapeutic indications. US 7183313 (February 27, 2007)
  23. Receptor selective cannabimimetic aminoalkylindoles. US 7173027 (February 6, 2007)
  24. Cannabimimetic lipid amides as useful medications. US 7161016 (January 9, 2007)
  25. Pyrazole derivatives as cannabinoid receptor antagonists. US 7119108 (October 10, 2006)
  26. Bifunctional agents possessing antioxidant and antiarrhythmic activity. US 7115657 (October 3, 2006)
  27. GABA A modulating neurosteroids. US 7064116 (June 20, 2006)
  28. Bicyclic and tricyclic cannabinoids. US 7057076 (June 6, 2006)
  29. Peripheral cannabinoid receptor (CB2) selective ligands. US 6995187 (February 7, 2006)
  30. Analgesic and immunomodulatory cannabinoids. US 6939977 (September 6, 2005)
  31. Cannabimimetic indole derivatives. US 6900236 (May 31, 2005)
  32. Anandamide inhibitors as analgesic agents. US 6391909 (May 21, 2002)
  33. Bicyclic cannabinoid agonists for the cannabinoid receptor. US 6943266 (September 13, 2005)
  34. Anandamide amidase inhibitors as analgesic agents. US 6579900 (June 17, 2003)
  35. Cannabinoids selective for the CB2 receptor. US 6166066 (December 26, 2000)
  36. Anandamide amidase inhibitors as analgesic agents. US 5874459 (February 23, 1999)
  37. Compositions useful as a cannabinoid receptor probe. US 5872148 (February 16, 1999)
  38. Phospholipid compounds and use thereof. US 5744459 (April 28, 1998)
  39. Anandamide amidase inhibitors as analgesic agents. US 5688825 (November 18, 1997)
  40. Phospholipid compounds and use thereof. US 5489580 (February 6, 1996)
  41. Compositions useful as a cannabinoid receptor probe. US 5440052 (August 8, 1995)

MENTORING ACTIVITIES:

Graduate, Post-Doctoral Students, and Visiting Scholars Directly Advised Since 2000 (University of Connecticut and Northeastern University, partial list)

  1. X. Tian, Ph.D., 1993-2004; Postdoctoral, 2004-2011.
  2. D. Lu, Ph.D., 1994-2005; Postdoctoral, 2005-2006
  3. H.F. Deng, M.Sc., Ph.D., 1995-2000
  4. R. Picone, Ph.D., 1995-2001; Postdoctoral, 2002-2004.
  5. T. Kourouli, Visiting Scholar (Greece), 1996-2001.
  6. X.Z. Lai, Ph.D., 1996-2004.
  7. J. Guo, Ph.D., 1996-2005; Postdoctoral, 2004-2005.
  8. Q. Liu, M.Sc., 1996-2002.
  9. R. Chari, Ph.D., 1998-2005.
  10. A. Ramamurthy, M.Sc., 1998-2001.
  11. A.K. Singh, M.Sc., 1999-2001.
  12. S. Palmer, Postdoctoral, 1999-2002.
  13. M. Sommer, Postdoctoral, 1999-2000.
  14. C. Souli, Postdoctoral, 1999-2000.
  15. F.M. Yao, Postdoctoral, 1999-2001.
  16. Y. Zhuang, Postdoctoral, 1999-2001.
  17. A. Zvonok, Postdoctoral, 1999-2002.
  18. S. Nikas, Postdoctoral, 1999-2003.
  19. R. Mercier, Postdoctoral, 2000-2006.
  20. T. Neelands, Postdoctoral, 2000-2001.
  21. H. Hu, Postdoctoral, 2000-2001.
  22. G. Thakur, Postdoctoral, 2000-2003.
  23. W. Xu, Ph.D., 2000-2006.
  24. C. Li, M.Sc., 2001-2004.
  25. C.R. Ramanathan, Postdoctoral, 2001- 2004.
  26. R. Thotapally, Postdoctoral, 2001-2004.
  27. Y.C. Leung, Postdoctoral, 2001-2004.
  28. P. McLaughlin, Postdoctoral, 2001-2005.
  29. J. Anday, Ph.D., 2001-2006.
  30. K. Winston, Ph.D., 2001-2006.
  31. S. Filppula, Postdoctoral, 2001-2006.
  32. S. Yaddanapudi, Ph.D., 2001-2007.
  33. P. Fan, Visiting Scholar (China), 2001- 2007; 2009-2010; 2011-2014.
  34. L. Pandarinathan, Postdoctoral, 2002- 2003.
  35. G. Choi, Postdoctoral, 2002-2004.
  36. J. Zhao, M.Sc., 2002-2005.
  37. Y. Pei, Ph.D., 2002-2007.
  38. D. Kazolias, M.Sc., 2002-2005.
  39. C. Rajan, M.Sc., 2002-2005.
  40. J. Wood, Postdoctoral, 2002-2005.
  41. S. Varadarajan, Postdoctoral, 2003-2004.
  42. L. Bizeta, Postdoctoral, 2003-2004.
  43. V. Veerappan, Postdoctoral, 2003-2004.
  44. T. Olszewska, Postdoctoral, 2003-2005.
  45. K.V. Subramanian, Postdoctoral, 2003- 2005.
  46. J. Zhang, M.Sc., 2003-2006.
  47. D. Fortin, Ph.D., 2003-2006.
  48. Y. Peng, M.Sc., 2003-2007; 2008-2009.
  49. C. Haile, Postdoctoral, 2004-2005.
  50. J. Williams, Ph.D., 2004-2007.
  51. K.R. Vemuri, Postdoctoral, 2004-2007.
  52. O.S. Alapafuja, Ph.D., 2004-2009.
  53. J. Zhai, Postdoctoral, 2005-2006.
  54. P. Holmberg, Postdoctoral, 2005-2006.
  55. E. Jutkiewicz, Postdoctoral, 2005-2006.
  56. K. Dzenko, Postdoctoral, 2005-2006.
  57. D. Karanian, Postdoctoral, 2005-2007.
  58. S. Divakaramenon, Postdoctoral, 2005- 2007.
  59. T. Parkkari, Visiting Scholar (Finland), 2005-2007.
  60. V. Magriotti, Visiting Scholar (Greece), 2006.
  61. P. Salgaonkar, Postdoctoral, 2006-2007.
  62. X. Han, Visiting Scholar (China), 2006- 2007.
  63. P.W. Qin, M.Sc., 2006-2008.
  64. A. Kastal, M.Sc., 2006-2009.
  65. J. Zhuang, Postdoctoral, 2006-2009.
  66. R. Sharma, Ph.D., 2006-2011.
  67. M. Johnston, Ph.D., 2006-2011.
  68. I. Karageorgos, Ph.D., 2006-2011.
  69. E. Shelnut, Ph.D., 2006-2011.
  70. D. Szymanski, Ph.D., 2006-2011.
  71. W. Aizu, Postdoctoral, 2006-2007.
  72. L. Song, Postdoctoral, 2006-2007.
  73. V. Shukla, Postdoctoral, 2006-2009.
  74. H. Teng, Ph.D., 2006-2011.
  75. D. Anagnostopoulos, Visiting Scholar (Greece), 2007.
  76. F. Desarnaud, Postdoctoral, 2007.
  77. H. Jang, Postdoctoral, 2007.
  78. S. Tyukhtenko, Postdoctoral, 2007-2010.
  79. C. Freni, M.Sc., 2007-2008.
  80. C. Kearn, Postdoctoral, 2007-2008.
  81. S. Gopalakrishnan, M.Sc., 2007-2008.
  82. S. Cararas, Postdoctoral, 2007-2008.
  83. A. Bowman, Postdoctoral, 2007-2009.
  84. I. Kendrick, Ph.D., 2007-2011.
  85. M. Papanastasiou, Postdoctoral, 2007- 2010.
  86. P. LeBeaume, Ph.D., 2007-2010.
  87. M. D’Souza, Ph.D., 2007-2011.
  88. S. Bajaj, Ph.D., 2007-2012.
  89. S. Tai, Ph.D., 2007-2012.
  90. P. Yin, Ph.D., 2007.
  91. H. Zhou, Ph.D., 2007-2014., Postdoc 2014-2016
  92. H. Li, Postdoctoral, 2007-2009.
  93. R. Serbanescu, M.Sc., 2008-2010.
  94. R. Tichkule, Ph.D., 2008-2012.
  95. M. Nasr, Ph.D., 2008-2012.
  96. K. Whitten, Ph.D., 2008-2012.
  97. C. Sallum, Postdoctoral, 2008-2009.
  98. D. Smith, Postdoctoral, 2008-2010.
  99. A. Rafalko, Ph.D., 2008-2011.
  100. S. Sanghavi, M.Sc., 2008-2009.
  101. S. Marathe, M.Sc., 2008-2009.
  102. V. Kodumuru, Postdoctoral, 2008-2010.
  103. S. Bhatt, M.Sc., 2009-2010.
  104. M. Johnson, Ph.D., 2009-2014.
  105. S.H. Chalasani, M.Sc., 2009-2010.
  106. B. Patel, M.Sc., 2009-2010.
  107. C. Mushti, Postdoctoral, 2009-2010.
  108. D. Finnegan, Postdoctoral, 2009-2011.
  109. K. Melchior, Postdoctoral, 2009-2010
  110. J. West, Postdoctoral, 2009-2013
  111. F. Sekyere, Ph.D., 2010.
  112. Y. Jmeian, Postdoctoral, 2010.
  113. A. Kulkarni, M.Sc., 2010-2011.
  114. L. Shen, Postdoctoral, 2010-2011.
  115. B. Zhang, Postdoctoral, 2010-2011.
  116. J. Garcia, Postdoctoral, 2010-2013.
  117. C. Habrukowich, Postdoctoral, 2010-2014.
  118. S. Ganguly, M.Sc., 2010-2011.
  119. G. Rajarshi, Ph.D. Candidate, 2010-.
  120. D. DeFilippo, M.Sc, 2011-2012.
  121. Y. Liu, Postdoctoral, 2011-2015.
  122. M. Williams, Postdoctoral 2011-2014
  123. A. Korde, Ph.D. Candidate, 2011-.
  124. M. Silva, Ph.D. Candidate, 2012-2013.
  125. M. Baradwan, Ph.D. Candidate, 2012-
  126. D. Felsing, Ph.D. Candidate, 2012-
  127. C. Honrao, Ph.D. Candidate, 2012-
  128. S. Kulkarni, Ph.D. Candidate, 2012-.
  129. S. Mallipeddi, Ph.D. Candidate, 2012-
  130. C. Miyabe, Ph.D. Candidate, 2012-.
  131. W. Zhang, M.Sc., 2012-2014; PhD. Candidate, 2014-.
  132. D. Pelekoudas, M.Sc., 2013-2015.
  133. P. Raje, M.Sc., 2013-2014.
  134. W. Zhu, M.Sc., 2013-2014.
  135. S. Jiang, Ph.D. Candidate, 2013-.
  136. B. Kochert, Ph.D. Candidate, 2013-.
  137. C. Perry, Ph.D. Candidate 2013-.
  138. B. Peng, M.Sc., 2013-2014; Ph.D Candidate 2014-.
  139. M. McCormack, Postdoctoral, 2013-.
  140. B. Suchomel, M.Sc., 2014.
  141. B. Wong, M.Sc., 2014.
  142. W. Wang, M.Sc., 2014-2015.
  143. Y. Liu, Ph.D. Candidate, 2014-.
  144. K. Mohammad, Ph.D. Candidate, 2014-.
  145. X. Ma, M.Sc., 2014; Ph.D. Candidate, 2015-
  146. J. Raghav, M.Sc. 2013-2014; Ph.D. Candidate, 2014-.
  147. X. Sun, Ph.D. Candidate, 2014-.